Binding of Reelin to its receptors induces Dab1 tyrosine phosphorylation and stimulates the activation of Src family tyrosine kinases and Akt serine/threonine kinase (Howell et al, 1999; Beffert et al, 2002; Ballif et al, 2003; Benhayon et al, 2003). Src, Fyn and Yes kinases are involved in Dab1 phosphorylation while phosphorylated Dab1 enhances their activity, suggesting a selfregulating tyrosinesignaling cascade (Arnaud et al, 2003; Bock and Herz, 2003). A possible downstream effector of phosphorylated Dab1 is glycogen synthase kinase 3 (GSK3), which is downregulated in response to Reelin signaling (Beffert et al, 2002; Ohkubo et al, 2003).Everyone in this valley is so negative.I wish the best for Austin Scott, however, besides one good game in the Orange Bowl he has yet to show me he is even a worth starting in college. If you knew some of the things that went on behind the scene at Parkland and how much about Scott was covered up and the special treatment he received you may ha